Sick of searching through mounds and mounds of third party apps that are supposed to make Twitter easier to use? Look no further than Brizzly.
Brizzy launched in July 2009, by Thing Labs, Inc. It is still currently in Beta, and you need an invitation to join, but they aren't that difficult to come by. Brizzly, which also works with Facebook allows inline media like photos, videos, and maps to show up in the direct feed. It also will allow you to put followers in groups, and to mute ones you don't want to hear from right now.
Brizzly to me. makes the Twitter experience much more enjoyable. One other plus, have you ever looked at the trending topics on Twitter and thought "huh"? Well, on Brizzly the trending topics have a "why?" link next to the topic and clicking it will tell you what it's a trending topic.
You can get a Brizzly invite from people currently using Brizzly, or on other various websites. Try it, and Brizzly will become your Twitter.