A series of storms struck Oklahoma, Kansas and Arkansas late Tuesday and early Wednesday, wiping out homes and businesses and killing at least nine people, emergency officials said.

A series of storms struck around midday, touching down in Caddo County, Okla., and then sweeping from the southwest to northeast corners of Canadian County, where it devastated El Reno, a town of 15,000 people about 25 miles west of downtown Oklahoma City. At least five people were killed and officials said the number could rise as search and rescue teams started to fan out across a state already battered by storms over the weekend.

At least 60 people were reported injured across central Oklahoma, many along the Interstate 40 corridor that runs past El Reno.

The tornado left a trail of shredded and overturned cars along I-40, destroyed livestock, set off a gas line explosion and spurred people across El Reno to evacuate their homes. Amy Brandley, the Canadian County flood plain manager, said emergency crews had only just begun to assess the damage. “Our county commissioner’s crews are out with heavy equipment clearing roads right now so search and rescues can take place,” she said.

The tornado that struck in El Reno was one of several across the state Tuesday. By 8 p.m., the National Weather Service had tornado watches in effect across 11 counties and was warning that “supercells” had developed across the central part of the state and were moving eastward. The agency posted an urgent alert on its Web site predicting an “outbreak of strong tornadoes” throughout late Tuesday.