It's the Saints offense vs. the 49ers defense.
The Saints are on the road in San Francisco, but as the Saints demonstrated last week, they can score when they need to and quickly.
The 49ers defense will be tested and look for them to be on their heels early.
Drew Brees with a big day and the Saints cover the 3.5 points. New Orleans with a big playoff win on the road.
Bonus play: The OVER in the Patriots/Broncos game. Over the 51.5.